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Nr1i2 Gene Detail
Summary
  • Symbol
    Nr1i2
  • Name
    nuclear receptor subfamily 1, group I, member 2
  • Synonyms
    mPXR, Pregnane X receptor, PXR, PXR.1, PXR.2, SXR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337040
    NCBI Gene: 18171
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38068711-38115211 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.64 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1302 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337040
 protein coding gene Chr16:38068685-38115211 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022809
 protein coding gene Chr16:36764484-36815008 (-)
A/J MGP_AJ_G0022774
 protein coding gene Chr16:34942868-34990330 (-)
AKR/J MGP_AKRJ_G0022746
 protein coding gene Chr16:36273744-36319822 (-)
BALB/cJ MGP_BALBcJ_G0022775
 protein coding gene Chr16:35055843-35108084 (-)
C3H/HeJ MGP_C3HHeJ_G0022539
 protein coding gene Chr16:36372723-36423824 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023222
 protein coding gene Chr16:37604706-37650150 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020737
 protein coding gene Chr16:35318357-35364631 (-)
CAST/EiJ MGP_CASTEiJ_G0022065
 protein coding gene Chr16:36524217-36576749 (-)
CBA/J MGP_CBAJ_G0022510
 protein coding gene Chr16:39256423-39311823 (-)
DBA/2J MGP_DBA2J_G0022642
 protein coding gene Chr16:34824525-34872239 (-)
FVB/NJ MGP_FVBNJ_G0022617
 protein coding gene Chr16:34855633-34903142 (-)
LP/J MGP_LPJ_G0022710
 protein coding gene Chr16:36448486-36499849 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022636
 protein coding gene Chr16:38374669-38432164 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023237
 protein coding gene Chr16:36231391-36277990 (-)
PWK/PhJ MGP_PWKPhJ_G0021805
 protein coding gene Chr16:35236262-35282008 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021636
 protein coding gene Chr16:36129743-36180759 (-)
WSB/EiJ MGP_WSBEiJ_G0022109
 protein coding gene Chr16:36302190-36353058 (-)



Homology
more
  • Human Ortholog
    NR1I2, nuclear receptor subfamily 1 group I member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR1I2, nuclear receptor subfamily 1 group I member 2
  • Synonyms
    BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
  • Links
    NCBI Gene ID: 8856
    neXtProt AC: NX_O75469
    UniProt: O75469

  • Chr Location
    3q13.33; chr3:119780484-119818487 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and fertile but exhibit specific loss of xenoregulation of CYP3A11.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    42
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    52
  • cDNA Data
    15
  • Literature Summary
    15
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18171 NCBI Gene Model | MGI Sequence Detail 46501 C57BL/6J ±  kb
transcript NM_010936 RefSeq | MGI Sequence Detail 2540 C57BL/6  
polypeptide O54915 UniProt | EBI | MGI Sequence Detail 431 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011397 nuclear receptor subfamily 1 group I member 2
    (term hierarchy)
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR050234 Nuclear hormone receptor family NR1 subfamily
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR035500 Nuclear hormone receptor-like domain superfamily
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 15
    Primer pair 2

    Microarray probesets 5
References
more
  • Summaries
    All 181
    Developmental Gene Expression 15
    Gene Ontology 14
    Phenotypes 100
  • Earliest
    J:50706 Bertilsson G, et al., Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12208-13
  • Latest
    J:349748 Shi T, et al., Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F(2alpha) (PGF(2alpha)) levels. Biochem Pharmacol. 2024 Jul;225:116309
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory